Helen Saibil's home page


Helen Saibil, FRS, FMedSci
Bernal Professor of Structural Biology
Crystallography, 
Department of Biological Sciences
ISMB
Birkbeck College
London WC1E 7HX, UK

email: h.saibil@mail.cryst.bbk.ac.uk

ISMB
BBK

Helen
Birkbeck EM lab
Research Interests
GroEL
The Saibil group studies the operation of macromolecular machines using three-dimensional electron microscopy. Our research projects are in the areas of molecular chaperones and assisted protein folding/unfolding, misfolding into amyloid, and protein refolding in membrane pore formation. On the cellular side, we are studying these processes in host cell interactions with intracellular pathogens. Our studies use single particle cryo-electron microscopy and electron tomography of isolated complexes, irregular assemblies and cell sections. In collaborative work, we combine these EM studies with fluorescence and atomic force microscopies.

Review on 3D EM
Orlova & Saibil
Chemical Reviews


Postdoc position available
Molecular and cellular mechanisms of protein disaggregation


EMBO course
Some current projects
Earlier work
Chaperones
Chaperones and protein disaggregation
amyloid
Amyloid assemblies
Photoreceptors
pores
Pores and host-pathogen interactions
Image processing
eBIC: electron Bio-Imaging Centre at Diamond Light Source