Research Projects
Elena Orlova
School of Crystallography
Birkbeck College London


Cryo EM map of latrotoxin, a pore-forming neurotoxin, from:
Structure of alpha-latrotoxin oligomers reveals that divalent cation-dependent tetramers form membrane pores. E. V. Orlova, M. A. Rahman, B. Gowen, K. E. Volynski, A. C. Ashton, C. Manser, M. van Heel & Y. A. Ushkaryov (2000) Nature Structural Biology 7, 48-53.

Some Recent Publications

Okorokov, A, Orlova, EV, Kingsbury, SR, Bagneris, C, Gohlke, U, Williams, GH & Stoeber, K (2004) Molecular structure of human geminin. Nature Struct. Mol. Biol. 11, 1021-1022.

White, HE, Saibil, HR, Ignatiou, A & Orlova, EV (2004) Recognition and separation of single particles with size variation by statistical analysis of their images. J. Mol. Biol. 336, 453-460.

Orlova, EV & Saibil, HR (2004) Structure determination of macromolecular assemblies by single-particle analysis of cryo-electron micrographs. Current Opin. Struct. Biol. 14, 584-590.

Voltage-gated K(+) Channel from Mammalian Brain: 3D Structure at 18 Å of the Complete (alpha)(4)(beta)(4) Complex. Orlova EV, Papakosta M, Booy FP, van Heel M, Dolly JO. (2003) J Mol Biol. 326(4):1005-12.

Structure of the Escherichia coli ribosomal termination complex with release factor Klaholz BP, Pape T, Zavialov AV, Myasnikov AG, Orlova EV, Vestergaard B, Ehrenberg M, van Heel M. (2003) Nature 421(6918):90-4.

Quaternary structure of the European spiny lobster (Palinurus elephas) 1x6-mer hemocyanin from cryoEM and amino acid sequence data. Meissner U, Stohr M, Kusche K, Burmester T, Stark H, Harris JR, Orlova EV, Markl J. (2003) J Mol Biol. 325(1):99-109.

Challenges at the frontiers of structural biology. Saibil HR, Orlova EV. (2002) Nat Struct Biol. 9(6):414-5.

Structural organisation of the head-to-tail interface of a bacterial virus. Lurz R, Orlova EV, Gunther D, Dube P, Droge A, Weise F, van Heel M, Tavares P. (2001) J Mol Biol. 310(5):1027-37.

Structural analysis of non-crystalline macromolecules: the ribosome. Orlova EV. (2000) Acta Crystallogr D 56 ( Pt 10):1253-8.

3D map of the plant photosystem II supercomplex obtained by cryoelectron microscopy and single particle analysis. Nield J, Orlova EV, Morris EP, Gowen B, van Heel M, Barber J. (2000) Nat Struct Biol. 7(1):44-7.

Structure of the 13-fold symmetric portal protein of bacteriophage SPP1. Orlova EV, Dube P, Beckmann E, Zemlin F, Lurz R, Trautner TA, Tavares P, van Heel M. (1999) Nat Struct Biol. 6(9):842-6.

Three-dimensional structure of low density lipoproteins by electron cryomicroscopy. Orlova EV, Sherman MB, Chiu W, Mowri H, Smith LC, Gotto AM Jr. (1999) Proc Natl Acad Sci USA. 96(15):8420-5.

EM group web page Elena Orlova