Cryo-electron microscopy of coat proteins



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Image created using EMD-1511, PDB-2QTV,3EFO,3MZK

Eukaryotic cells are organised in membrane-bound compartments that constantly and actively exchange material. Coat complexes promote transport of proteins between compartments by generating cargo-loaded membrane vesicles. Tight regulation of traffic ensures that each class of protein is delivered to the right place at the right time, so that cells can function smoothly and communicate with each other.

The first step in trafficking, cargo exit from the endoplasmic reticulum (ER), is mediated by the COPII coat.
I use a combination of biochemistry and structural biology to understand how COPII function is regulated to promote secretion of large extracellular matrix components such as procollagens. Find out more.


My lab is part of the Institute of Structural and Molecular Biology at Birkbeck College.

Contact details:

Department of Biological Sciences, Birkbeck College
Malet St. London, WC1E 7HX
02076316898
g.zanetti@mail.cryst.bbk.ac.uk

Work in the lab is funded by the Royal Society.