Roberts Lab

Hesketh SJ, Mukhopadhyay AM, Nakamura D, Toropova K, Roberts AJ (2022) IFT-A structure reveals carriages for membrane protein transport into cilia. Cell.

Vig A, Poulter JA, Ottaviani D, Tavares E, Toropova K, Tracewska AM, Mollica A, Kang J, Kehelwathugoda O, Paton T, Maynes JT, Wheway G, Arno G, Genomics England Research Consortium, Khan KN, McKibbin M, Toomes C, Ali M, Di Scipio M, Li S, Ellingford J, Black G, Webster A, Rydzanicz M, Stawiński P, Płoski R, Vincent A, Cheetham ME, Inglehearn CF, Roberts AJ, Heon E. (2020) DYNC2H1 hypomorphic or retina-predominant variants cause nonsyndromic retinal degeneration. Genetics in Medicine 22:2041–2051.

Webb S, Mukhopadhyay AG, Roberts AJ. (2020) Intraflagellar transport trains and motors: Insights from structure. Seminars in Cell & Developmental Biology 107:82-90.

Toropova K, Zalyte R, Mukhopadhyay AG, Mladenov M, Carter AP, Roberts AJ. (2019) Structure of the dynein-2 complex and its assembly with intraflagellar transport trains. Nature Structural & Molecular Biology 26(9):823-829.

Research highlight in Science

Roberts AJ. (2018) Emerging mechanisms of dynein transport in the cytoplasm versus the cilium. Biochemical Society Transactions pii: BST20170568.

Atherton J, Jiang K, Stangier MM, Luo Y, Hua S, Houben K, van Hooff JJE, Joseph AP, Scarabelli G, Grant BJ, Roberts AJ, Topf M, Steinmetz MO, Baldus M, Moores CA, Akhmanova A. (2017) A structural model for microtubule minus-end recognition and protection by CAMSAP proteins. Nature Structural & Molecular Biology 24(11):931-943.

Toropova K, Mladenov M, Roberts AJ. (2017) Intraflagellar transport dynein is autoinhibited by trapping of its mechanical and track-binding elements. Nature Structural & Molecular Biology 24(5):461-468.

Toropova K*, Zou S*, Roberts AJ, Redwine WB, Goodman BS, Reck-Peterson SL, Leschziner AE. (2014) Lis1 regulates dynein by sterically blocking its mechanochemical cycle. eLIFE. 3:e03372
*Co-first authors

Roberts AJ, Goodman BS, Reck-Peterson SL. (2014) Reconstitution of dynein transport to the microtubule plus end by kinesin. eLIFE. 3:e02641

Tan K, Roberts AJ, Chonofsky M, Egan MJ, Reck-Peterson SL. (2014) A Microscopy-based Screen Employing Multiplex Genome Sequencing Identifies Cargo-Specific Requirements for Dynein Velocity. MBoC. 25(5):669-78.

Roberts AJ, Kon T, Knight PJ, Sutoh K, Burgess SA. (2013) Functions and mechanics of dynein motor proteins. Nature Reviews Molecular Cell Biology. 14:713-726

Huang J*, Roberts AJ*, Leschziner AE, Reck-Peterson SL. (2012) Lis1 acts as a "clutch" between the ATPase and microtubule-binding domains of the dynein motor. Cell 150(5):975-86.
*Co-first authors
Feature by Martina Trokter & Thomas Surrey

Roberts AJ, Malkova B, Walker ML, Sakakibara H, Numata N, Kon T, Ohkura R, Edwards TA, Knight PJ, Sutoh K, Oiwa K, Burgess SA. (2012) ATP-driven remodeling of the linker domain in the dynein motor. Structure 20(10):1670-80.

Roberts AJ, Burgess SA. (2011) Structural Studies on the Dynein Heavy Chain. Handbook of Dynein Pan Stanford Publishing. Editors: Keiko Hirose & Linda Amos.

Roberts AJ, Burgess SA. (2009) Electron Microscopic Imaging and Analysis of Isolated Dynein Particles. Methods in Cell Biology 91:41-61. Editors: Stephen King & Gregory Pazour.

Roberts AJ, Numata N, Walker ML, Kato YS, Malkova B, Kon T, Ohkura R, Arisaka F, Knight PJ, Sutoh K, Burgess SA. (2009) AAA+ Ring and linker swing mechanism in the dynein motor. Cell 136(3):485-95.

Feature by Andrew Carter & Anne Houdusse
Research highlight by Biopolymers

Kon T, Imamula K, Roberts AJ, Ohkura R, Knight PJ, Gibbons IR, Burgess SA, Sutoh K. (2009) Helix sliding in the stalk coiled coil of dynein couples ATPase and microtubule binding. Nature Structural & Molecular Biology 16(3):325-33.