We are investigating the mechanisms by which molecules are spatially organized within living cells. A main focus is on dynein, a large but poorly understood motor protein that uses ATP hydrolysis to transport cellular components and signals along microtubules. The overarching goal of our research is to understand how dynein works as a force-generating machine, and how dynein molecules are regulated to bring about coherent cellular functions. We are also interested in how defects in the dynein machinery cause human disease, and how dynein operates with the other class of microtubule motor, kinesin. Core techniques in our research are cryo-electron microscopy, in vitro reconstitution, cell biology, and single-molecule fluorescence microscopy.
We are based at the Institute of Structural and Molecular Biology, a joint Institute between Birkbeck and UCL. We are members of the Birkbeck Electron Microscopy and Image Processing group. We gratefully acknowledge support from the Wellcome Trust, Royal Society, EMBO, and BBSRC.