Research focus

Spatial organization within cells | mechanism and regulation of dynein

We are investigating the mechanisms by which molecules are spatially organized within living cells. A main focus is on dynein, a large but poorly understood motor protein that uses ATP hydrolysis to transport cellular components and signals along microtubules. The overarching goal of our research is to understand how dynein works as a force-generating machine, and how dynein molecules are regulated to bring about coherent cellular functions. We are also interested in how defects in the dynein machinery cause human disease, and how dynein operates with the other class of microtubule motor, kinesin. Core techniques in our research are cryo-electron microscopy, protein engineering, cell biology, and single-molecule fluorescence microscopy.

We gratefully acknowledge support from the Wellcome Trust, Royal Society, and BBSRC.


Oct 2017

Stephanie Webb joins the lab for a PhD rotation project. Welcome Steph!
We have collaborated with Bara Malkova at Science Animated () to create impressions of dynein-2 in action (see image 2 in the slider).
Anthony gives a talk at the Dynein 2017 International Workshop in Japan.

May 2017

Paper on dynein-2 auto-regulation is published in Nature Structural & Molecular Biology. Congratulations Kat and Miro!

April 2017

Kat gives a talk at the British Microtubule Meeting!

January 2017

The lab receives a BBSRC New Investigator Award.

September 2016

Anthony receives the Biochemical Society Early Career Research Award 2016: Molecular Structure and Function.