Institute of Structural and Molecular Biology @ Birkbeck / UCL 

Crystallography/Biological Sciences, Birkbeck

University of London

Malet Street

London WC1E 7HX


Phone:  +44 (0)20 7079 0886

Maya Topf

Academic Biography

- 2016 - Professor, ISMB and Birkbeck, University of London

- 2013 - Reader, ISMB and Birkbeck, University of London

- 2012 - Lecturer, ISMB and Birkbeck, University of London

  1. -2006 - MRC Career Development Fellow: ISMB and Birkbeck, London

  2. -2003 - Post-doctoral research: University of California San Francisco (Andrej Sali lab)

- 2002 - D.Phil: University of Oxford

Research Areas

  1. -3D electron microscopy image analysis;

  2. -Structures of macromolecular assemblies by data integration;

  3. -Protein-protein interaction networks;

  4. -Modelling of membrane proteins;

  5. -Herpesviruses, ligand-gated ion channels, microtubule complexes

Selected recent publications

  1. Zeev-Ben-Mordehai T, et al. “Two distinct trimeric conformations of natively membrane-anchored full-length Herpes simplex virus 1 glycoprotein B”. Proc Natl Acad Sci USA. 113:4176-4181, 2016.

  2. Ashford P, et al. “HVint: A strategy for identifying novel protein-protein interactions in herpes simplex virus type 1”.          Mol Cell Proteomics. 15:2939-2953, 2016.

  3. Bullock JMA, et al. “The importance of non-accessible crosslinks and solvent accessible surface distance in modelling proteins with restraints from crosslinking mass spectrometry.” Mol Cell Proteomics, 2016, 15:10.1074.

  4. Joseph AP, et al. “Refinement of atomic models in high resolution EM reconstructions using Flex-EM and local assessment.” Methods 100:42, 2016

  5. Pandurangan AP, et al. “γ-TEMPy: simultaneous fitting of components in 3D-EM maps of their assembly using a genetic algorithm”. Structure, 23:2365, 2015.

  6. Lukoyanova N, et al. “Conformational changes during pore formation by the perforin-related protein pleurotolysin”.      PLoS Biol. 13(2): e1002049, 2015.

Institute of Structural and Molecular Biology, Birkbecl/UCL, London