Contact
Institute of Structural and Molecular Biology @ Birkbeck / UCL
Crystallography/Biological Sciences, Birkbeck
University of London
Malet Street
London WC1E 7HX
UK
Phone: +44 (0)20 7079 0886
Contact
Institute of Structural and Molecular Biology @ Birkbeck / UCL
Crystallography/Biological Sciences, Birkbeck
University of London
Malet Street
London WC1E 7HX
UK
Phone: +44 (0)20 7079 0886
Maya Topf
Academic Biography
- 2016 - Professor, ISMB and Birkbeck, University of London
- 2013 - Reader, ISMB and Birkbeck, University of London
- 2012 - Lecturer, ISMB and Birkbeck, University of London
-2006 - MRC Career Development Fellow: ISMB and Birkbeck, London
-2003 - Post-doctoral research: University of California San Francisco (Andrej Sali lab)
- 2002 - D.Phil: University of Oxford
Research Areas
-3D electron microscopy image analysis;
-Structures of macromolecular assemblies by data integration;
-Protein-protein interaction networks;
-Modelling of membrane proteins;
-Herpesviruses, ligand-gated ion channels, microtubule complexes
Selected recent publications
•Cragnolini T, et al. The TEMPy2: A python library with improved 3D electron microscopy density fitting and validation workflows. Acta Cryst Section D. (in press).
•Vollmer B, et al. The pre-fusion structure of Herpes simplex virus glycoprotein B. Science Advances 6: eabc1726.
•Sinnott M et al. Combining Information from Crosslinks and Monolinks in the Modelling of Protein Structures. Structure 28:1-10, 2020.
•Hernández Durán A, et al. Protein interactions and consensus clustering analysis uncover insights into herpesvirus virion structure and function relationships. PLoS Biol, 17(6):e3000316, 2019.
•Bullock JMA, Schwab J, et al. “The importance of non-accessible crosslinks and solvent accessible surface distance in modelling proteins with restraints from crosslinking mass spectrometry.” Mol Cell Proteomics, 2016, 15:10.1074.
•Joseph AP, Malhotra S, et al. “Refinement of atomic models in high resolution EM reconstructions using Flex-EM and local assessment.” Methods 100:42, 2016.
Institute of Structural and Molecular Biology, Birkbecl/UCL, London