Academic Biography:

Post-doctoral research: University of California San Francisco

D.Phil: University of Oxford

Research Interests:

Development and application of methods in computational structural biology. Structure and function characterisation of macromolecular assemblies by a combination of experimental data, bioinformatics, and modelling techniques. In particular, analysis of low-resolution data from cryo electron microscopy and tomography.

Selected publications:

1. •Pandurangan AP and Topf M. Finding rigid bodies in protein structures: Application to flexible fitting into cryoEM maps. J Struct Biol (in press).
   

2. •Vasishtan and Topf (2011) Scoring functions for cryoEM density fitting. J Struct Biol 174:333-343.
   

3. •Zhang et al. (2010) A fast mathematical programming procedure for simultaneous fitting of assembly components into cryo-EM density maps. Bioinformatics 26:i261-8.
   

4. •Topf et al. (2008) Protein structure fitting and refinement guided by CryoEM density. Structure 16: 295-307.