Institute of Structural and Molecular Biology @ Birkbeck / UCL 

Crystallography/Biological Sciences, Birkbeck

University of London

Malet Street

London WC1E 7HX


Phone:  +44 (0)20 7079 0886

Maya Topf

Academic Biography

- 2016 - Professor, ISMB and Birkbeck, University of London

- 2013 - Reader, ISMB and Birkbeck, University of London

- 2012 - Lecturer, ISMB and Birkbeck, University of London

  1. -2006 - MRC Career Development Fellow: ISMB and Birkbeck, London

  2. -2003 - Post-doctoral research: University of California San Francisco (Andrej Sali lab)

- 2002 - D.Phil: University of Oxford

Research Areas

  1. -3D electron microscopy image analysis;

  2. -Structures of macromolecular assemblies by data integration;

  3. -Protein-protein interaction networks;

  4. -Modelling of membrane proteins;

  5. -Herpesviruses, ligand-gated ion channels, microtubule complexes

Selected recent publications

  1. Cragnolini T, et al. The TEMPy2: A python library with improved 3D electron microscopy density fitting and validation workflows. Acta Cryst Section D. (in press).

  2. Vollmer B, et al. The pre-fusion structure of Herpes simplex virus glycoprotein B. Science Advances 6: eabc1726.

  3. Sinnott M et al. Combining Information from Crosslinks and Monolinks in the Modelling of Protein Structures. Structure 28:1-10, 2020.

  4. Hernández Durán A, et al. Protein interactions and consensus clustering analysis uncover insights into herpesvirus virion structure and function relationships. PLoS Biol, 17(6):e3000316, 2019.

  5. Bullock JMA, Schwab J, et al. “The importance of non-accessible crosslinks and solvent accessible surface distance in modelling proteins with restraints from crosslinking mass spectrometry.” Mol Cell Proteomics, 2016, 15:10.1074.

  6. Joseph AP, Malhotra S, et al. “Refinement of atomic models in high resolution EM reconstructions using Flex-EM and local assessment.” Methods 100:42, 2016

Institute of Structural and Molecular Biology, Birkbecl/UCL, London