Institute of Structural and Molecular Biology @ Birkbeck / UCL 

Crystallography/Biological Sciences, Birkbeck

University of London

Malet Street

London WC1E 7HX


Phone:  +44 (0)20 7079 0886

Maya Topf

Academic Biography

- 2016 - Professor, ISMB and Birkbeck, University of London

- 2013 - Reader, ISMB and Birkbeck, University of London

- 2012 - Lecturer, ISMB and Birkbeck, University of London

  1. -2006 - MRC Career Development Fellow: ISMB and Birkbeck, London

  2. -2003 - Post-doctoral research: University of California San Francisco (Andrej Sali lab)

- 2002 - D.Phil: University of Oxford

Research Areas

  1. -3D electron microscopy image analysis;

  2. -Structures of macromolecular assemblies by data integration;

  3. -Protein-protein interaction networks;

  4. -Modelling of membrane proteins;

  5. -Herpesviruses, ligand-gated ion channels, microtubule complexes

Selected recent publications

  1. Bullock JMA, Sen N, et al. Modelling protein complexes using restraints from cross-linking mass spectrometry. Structure 26:1015-1024, 2018.

  2. Locke J, Joseph AP, et al. “Molecular basis of human kinesin-8 function and inhibition.” Proc Natl Acad Sci USA 114:E9539-E9548, 2017.

  3. Joseph AP et al. “Integrative modelling of cellular assemblies.” Curr Opin Struct Biol 46:102, 2017

  4. Ashford P, Hernandez A, et al. “HVint: A strategy for identifying novel protein-protein interactions in herpes simplex virus type 1”. Mol Cell Proteomics 15:2939, 2016.

  5. Bullock JMA, Schwab J, et al. “The importance of non-accessible crosslinks and solvent accessible surface distance in modelling proteins with restraints from crosslinking mass spectrometry.” Mol Cell Proteomics, 2016, 15:10.1074.

  6. Joseph AP, Malhotra S, et al. “Refinement of atomic models in high resolution EM reconstructions using Flex-EM and local assessment.” Methods 100:42, 2016

Institute of Structural and Molecular Biology, Birkbecl/UCL, London