A collaboration with scientists at UCL, reveals the physical constrains on evolutionary adaptation in RubisCO, the enzyme that fixes CO2 in plants.

New analysis on the controversial topic of enthalpy-entropy compensation shows, for the first time, how the extent of compensation varies from system to system

A collaboration with scientists at the Institute of Cancer Research identifies the Destruction Box receptor, which regulates chromosome separation during cell division

Mark A. Williams

Director, ISMB Biophysics Centre
and Lecturer in Biophysics
School of Crystallography
Birkbeck College, Malet Street
London WC1E 7HX
phone: +44 (0)20 7079 0659
fax: +44 (0)20 7631 6803


Reasearch in my group aims to understand protein structure-function relationships in basic cellular processes and disease states. Through a multi-disciplinary approach using biophysical and structural experimental methods, structural bioinformatic analysis and physics-based molecular simulation, we aim to develop as complete as possible an understanding of the formation of biomolecular complexes. We aim to ulitise this knowledge to combat disease via structure-based drug discovery and design, particularly in the area of anti-microbial therapy.


Undergraduate training in Physics at the University of Birmingham
PhD Computational Biophysics, with Julia Goodfellow at the then Crystallography Dept, Birkbeck
Computational postdoctoral research on protein hydration and folding with Julia and Janet Thornton (UCL)
MRC Research Fellowship focussed on experimental NMR held in Jim Feeney's group at the NIMR
Senior Postdoc leading computational and NMR projects in John Ladbury's group at UCL