Claire Naylor

Publication List

 

 

Staphylococcal superantigen-like proteins

Al-Shangiti, A.M.*, Naylor, C.E.*, Nair, S.P., Briggs, D.C., Henderson, B. and Chain, B.M. Structural relationships and cellular tropism of staphylococcal superantigen like proteins. Infect. Immun. 72, 4261-70 (2004).*These authors contributed equally to the work.

 

C. perfringens a-toxin

 

Clark, G.C., Briggs, D.C., Karasawa, T., Wang, X, Cole, A.R., Maegawa, T., Jayasekara, P.N., Naylor, C.E., Miller, J. Moss, D.S., Nakamura, S., Basak, A.K. and Titball, R.W.  Clostridium absonum a-toxin: new insights into Clostridial phospholipase C substrate binding and specificity.  J. Mol. Biol. 33, 759-69 (2003).

 

Justin, N., Walker, N., Bullifent, H.L., Songer, G., Jost, H., Naylor, C.E., Miller, J., Moss, D.S., Titball, R.W. and Basak, A.K.  The first strain of Clostridium perfringens isolated from an avian source has an alpha-toxin with divergent structural and kinetic properties.  Biochemistry 41, 6253-6262 (2002).

 

Eaton, J.T., Naylor, C.E., Howells, A.M., Moss, D.S., Titball, R.W. and Basak, A.K. Crystal structure of the C. perfringens alpha-toxin with the active site closed by a flexible loop region.  J. Mol. Biol. 319, 275-281 (2002)

 

Giron, A.A, Flores-Diaz, M., Guillouard, I., Naylor, C.E., Titball, R.W., Rucavado, A. Cole, S., Lomonte, B,. Basak, A.K., Gutierrez, J.M., Thelestam, M.  Mapping critical residues for toxicity in Clostridium perfringens phospholiapse C, the key toxin in gas gangrene.  Eur J. Biochem. Eur. J. Biochem. 267, 5191-5197 (2000).

 

Naylor, C.E., Jepson, M., Crane, D.T., Titball, R.W., Miller, J., Basak, A.K. and Bolgiano, B.  Characterisation of the calcium-binding C-terminal domain of Clostridium perfringens alpha-toxin.  Journal of Molecular Biology, 294, 757-770 (1999).

 

Titball, R.W., Naylor, C.E., Basak, A.K.  The Clostridium perfringens a-toxin. Anaerobe 5, 51-64 (1999).

 

 

Naylor, C.E., Eaton, J.T., Howells, A., Justin, N., Moss, D.S., Titball, R.W. & Basak, A.K.  The structure of the key toxin in gas-gangrene.  Nature Structural Biology 5, 738-746 (1998).

 

Basak, A.K., Eaton, J.T., Moss, D.S., Naylor, C.E., Howells, A., Miller, J. & Titball, R.W. Crystallisation and preliminary X-ray diffraction studies of a-toxin from two different strains (NCTC-8237 and CER89L43) of Clostridium perfringens. Acta Cryst. D54, 1425-1428 (1998).

 

Justin, N., Eaton, J.T., Naylor, C.E., Howells, A., Moss, D.S., Titball, R.W. and Basak, A.K. Structure function studies of Clostridium perfringens alpha-toxin; a gas-gangrene causing protein.  Proceedings of the 5th International Symposium of Protein Structure-Function Relationships (1996).


Ceruloplasmin-related proteins

 

Chen, H.*, Attiehl, Z.K.*, Su T., Syed, B.A., Gao, H., Alaeddine, R.M., Fox, T.C., Usta, J., Naylor, C.E., Evans, R.W., McKie, A.T., Anderson, G.J. and Vulpe, C.D. Hephaestin is a ferroxidase that maintains partial activity in the sex linked anemia mice. Submitted to Blood.

 

Syed B.A., Beaumont N.J., Patel A., Naylor C.E., Bayele H.K., Joannou C.L., Rowe P.S., Evans R.W., Srai S.K..  Analysis of the human hephaestin gene and protein: comparative modelling of the N-terminus ecto-domain based upon ceruloplasmin.  Protein Eng. 15, 205-214 (2002). 

 

Glucose 6-phosphate dehydrogenase

 

Naylor, C. E., Gover, S., Basak, A. K., Cosgrove, M. S., Levy, H. R. & Adams, M. J.

(2001). NADP+ and NAD+ binding to the dual coenzyme specific enzyme Leuconostoc

mesenteroides glucose 6-phosphate dehydrogenase: different interdomain hinge angles

are seen in different binary and ternary complexes. Acta Cryst. D57, 635-648.

 

Au, S.W.N, Naylor, C.E., Gover, S., Vandeputte-Rutten, L., Scopes, D.A., Mason, P.J., Luzzatto, L., Lam, V.M.S. and Adams, M.J.  Solution of the structure of tetrameric human glucose 6-phosphate dehydrogenase by molecular replacement.  Acta Cryst. D55, 826-834 (1999).

 

Scopes, D.A., Bautista, J.M., Naylor, C.E., Adams, M.J. & Mason, P.J. Amino acid substitutions at the dimer interface of human glucose 6-phosphate dehydrogenase that increase the thermostability and reduce the stabilising effect of NADP.  European Journal of Biochemistry 251, 382-389 (1998).

 

Cosgrove, M.S., Naylor, C.E., Paludan, S., Adams, M.J. & Levy, H.R.  On the mechanism of the reaction catalysed by glucose 6-phosphate dehydrogenase.  Biochemistry 37, 2759-2769 (1998).

 

Naylor, C.E., Rowland, P., Basak, A.K., Gover, S., Mason, P.J., Bautista, J.M., Vulliamy, T.J., Luzzatto, L. & Adams, M.J. Glucose 6-phosphate dehydrogenase mutations causing enzyme deficiency in a model of the tertiary structure of the human enzyme.  Blood 87, 2974-2982 (1996).

 

Adams, M.J., Ellis, G.H., Gover, S., Naylor, C.E. & Phillips, C.  Crystallographic study of coenzyme, coenzyme analogue and substrate binding in 6-phosphogluconate dehydrogenase: Implications for NADP specificity and the enzyme mechanism.  Structure 2, 651-668 (1994).

 

Others

 

Dohnalek, J., Hasek, J., Brynda, J., Fabry, M., Sedlacek, J., Konvalinka, J., Hradilek, M., Soucek, M., Adams, M.J. and Naylor, C.E.  Peptidomimetic inhibitors complexed with HIV-1 protease: crystallisation for X-ray diffraction studies.  Gen. Physiol. Biophys. 17, suppl. 1:9-11 (1998).

 

Basak, A.K., Kroone, R.C., Lubsen, N.H., Naylor, C.E., Jaenicke, R. and Slingsby, C.  The C-terminal domains of gS-crystallin pair about a distorted twofold axis.  Protein Engineering 11, 337-344 (1998).