Recent publications

Elena Orlova

1. Lhuillier S, Gallopin M, Gilquin B, Brasilès S, Lancelot N, Letellier G, Gilles M, Dethan G, Orlova EV, Couprie J, Tavares P, Zinn-Justin S. (2009) Structure of bacteriophage SPP1 head-to-tail connection reveals mechanism for viral DNA gating. Proc Natl Acad Sci USA. 106(21), 8507-8512.

2. Orlova EV. How viruses infect bacteria? (2009) EMBO J. 28(7), 797-798.

3. White HE, Hodgkinson JL, Jahn TR, Cohen-Krausz S, Gosal WS, Müller S, Orlova EV, Radford SE, Saibil HR. (2009) Globular tetramers of beta(2)-microglobulin assemble into elaborate amyloid fibrils. J. Mol Biol. 389(1), 48-57.

4. Okorokov AL, Orlova EV. (2009) Structural biology of the p53 tumour suppressor. Curr Opin Struct Biol. 19(2), 97-202. Review.

5. Fronzes R, Schäfer E, Wang L, Saibil HR, Orlova EV, Waksman G. (2009) Structure of a type IV secretion system core complex. Science. 323(5911), 266-268.

6. Salih O, Remaut H, Waksman G, Orlova EV. (2008) Structural analysis of the Saf pilus by electron microscopy and image processing. J Mol Biol. 23, 174-187

7. Elad N, Clare DK, Saibil HR, Orlova EV. (2008) Detection and separation of heterogeneity in molecular complexes by statistical analysis of their two-dimensional projections. J Struct Biol. 162, 108-120

8. Okorokov AL, Waugh A, Hodgkinson J, Murthy A, Hong HK, Leo E, Sherman MB, Stoeber K, Orlova EV, Williams GH. (2007) Hexameric ring structure of human MCM10 DNA replication factor. EMBO Rep. 10, 925-930

9. Plisson C, White HE, Auzat I, Zafarani A, São-José C, Lhuillier S, Tavares P, Orlova EV. (2007) Structure of bacteriophage SPP1 tail reveals trigger for DNA ejection. EMBO J. 26, 3720-3728

10. Lebedev AA, Krause MH, Isidro AL, Vagin AA, Orlova EV, Turner J, Dodson EJ, Tavares P, Antson AA. (2007) Structural framework for DNA translocation via the viral portal protein. EMBO J. 26, 1984-1994.

11. Elad N, Farr GW, Clare DK, Orlova EV, Horwich AL, Saibil HR. (2007) Topologies of a substrate protein bound to the chaperonin GroEL. Mol Cell. 26, 415-426.

12. Wyatt K, White H, Wang L, Bateman O, Slingsby C, Orlova EV, Wistow G. (2006) Lengsin is a survivor of an ancient family of class I glutamine synthetases in eukaryotes that has undergone evolutionary re-engineering for a tissue-specific role in the vertebrate eye lens Structure 14(2), 1823-1834

13. Okorokov AL, Sherman MB, Plisson C, Grinkevich V, Sigmundsson K, Selivanova G, Milner J, Orlova EV. (2006) The structure of p53 tumour suppressor protein reveals the basis for its functional plasticity. EMBO J. 25/21, 5191–5200

14. Sherman MB, Guenther RH, Tama F, Sit TL, Brooks CL, Mikhailov AM, Orlova EV, Baker TS, Lommel SA. (2006) Removal of divalent cations induces structural transitions in red clover necrotic mosaic virus revealing a potential mechanism for RNA release. J Virol. 80(21), 10395-10406 (Front cover)

15. White HE, Orlova EV, Chen S, Wang L, Ignatiou A, Gowen B, Stromer T, Franzmann TM, Haslbeck M, Buchner J, Saibil HR. (2006) Multiple distinct assemblies reveal conformational flexibility in the small heat shock protein hsp26. Structure. 14, 1197-1204.

16. Clare DK, Orlova EV, Finbow MA, Harrison MA, Findlay JB, Saibil HR. (2006) An expanded and flexible form of the vacuolar ATPase membrane sector. Structure 14(7), 1149-1156.

17. Orlova, EV & Saibil, HR (2004) Structure determination of macromolecular assemblies by single-particle analysis of cryo-electron micrographs. Current Opin. Struct. Biol. 14, 584-590.

18. Okorokov, A, Orlova, EV, Kingsbury, SR, Bagneris, C, Gohlke, U, Williams, GH & Stoeber, K (2004) Molecular structure of human geminin. Nature Struct. Mol. Biol. 11, 1021-1022.

19. White, HE, Saibil, HR, Ignatiou, A & Orlova, EV (2004) Recognition and separation of single particles with size variation by statistical analysis of their images. J. Mol. Biol. 336, 453-460.

20. Orlova, EV & Saibil, HR (2004) Structure determination of macromolecular assemblies by single-particle analysis of cryo-electron micrographs. Current Opin. Struct. Biol. 14, 584-590.

21. Orlova EV, Papakosta M, Booy FP, van Heel M, Dolly JO. (2003)Voltage-gated K(+) Channel from Mammalian Brain: 3D Structure at 18 Angsterm of the complete (alpha)(4)(beta)(4) Complex. J Mol Biol. 326, 1005-1012.

22. Klaholz BP, Pape T, Zavialov AV, Myasnikov AG, Orlova EV, Vestergaard B, Ehrenberg M, van Heel M. (2003) Structure of the Escherichia coli ribosomal termination complex with release factor Nature 421, 90-94.

23. Saibil HR, Orlova EV. (2002) Challenges at the frontiers of structural biology. Nat Struct Biol. 9(6), 414-415.

24. Lurz R, Orlova EV, Gunther D, Dube P, Droge A, Weise F, van Heel M, Tavares P. (2001) Structural organisation of the head-to-tail interface of a bacterial virus. J Mol Biol. 310, 1027-1037.

25. Orlova EV. (2000) Structural analysis of non-crystalline macromolecules: the ribosome. Acta Crystallogr D 56 ( Pt 10), 1253-1258.

26. Orlova EV, Dube P, Beckmann E, Zemlin F, Lurz R, Trautner TA, Tavares P, van Heel M. (1999) Structure of the 13-fold symmetric portal protein of bacteriophage SPP1. Nat Struct Biol. 6, 842-846.

EM group web page Elena Orlova