Recent publications

Elena Orlova

1. White HE, Sherman MB, Brasilès S, Jacquet E, Seavers P, Tavares P, Orlova EV. (2012)Capsid structure and its Stability at the Late Stages of Bacteriophage SPP1 Assembly. J Virol. Apr 18. [Epub ahead of print]

2. Orlova EV, (2011),Bacteriophages and their structural organisation. In Bacteriophages,(Ed. Kurtboke) InTech Open, open access publisher,3-30.

3. Tavares P., Zinn-Justin S., and Orlova, E.V. (2011). Genome gating in tailed bacteriophage capsids. In Viral Molecular Machines (M.G. Rossmann, V.B. Rao, eds.), Springer, New York, 585-600 (1)

4. Orlova EV, Saibil HR, (2011) Structural analysis of macromolecular assemblies by electron microscopy. Chemical Reviews, 111(12), 7710-7748 (2)

5. R. Aramayo, M. B. Sherman, K. Brownless, A. L. Okorokov and E. V. Orlova. (2011) Quaternary structure of the specific p53-DNA complex reveals the mechanism of p53 mutant dominance. NAR, 39 (20), 8960-8971 (1).

6. Law RHP, Lukoyanova N, Voskoboinik I, Caradoc-Davies TT, Baran K, Dunstone MA, Angelo MED, Orlova EV, Coulibaly F, Verschoor S, Browne KA, Ciccone A, Kuiper MJ, Bird FI, Trapani JA, Saibil HR, Whisstock JC. (2010) The structural basis for membrane binding and pore formation by lymphocyte perforin. Nature, 468, 447-51.(23)

7. Orlova EV, Saibil HR.(2010) Methods for three-dimensional reconstruction of heterogeneous assemblies. Methods Enzymol.,482, 321-41, Review.(5)

8. Clare DK, Orlova EV. (2010)4.6A Cryo-EM reconstruction of tobacco mosaic virus from images recorded at 300keV on a 4kx4k CCD camera. J Struct Biol. 171, 303-308. (7)

9. Okorokov AL, Chaban YL, Bugreev DV, Hodgkinson J, Mazin AV, Orlova EV. Structure of the hDmc1-ssDNA filament reveals the principles of its architecture. (2010) PLoS One. 5(1):e8586 (4)

10. Lhuillier S, Gallopin M, Gilquin B, Brasilès S, Lancelot N, Letellier G, Gilles M, Dethan G, Orlova EV, Couprie J, Tavares P, Zinn-Justin S. (2009) Structure of bacteriophage SPP1 head-to-tail connection reveals mechanism for viral DNA gating. Proc Natl Acad Sci USA. 106(21), 8507-8512.

12. Orlova EV. How viruses infect bacteria? (2009) EMBO J. 28(7), 797-798.

13. White HE, Hodgkinson JL, Jahn TR, Cohen-Krausz S, Gosal WS, Müller S, Orlova EV, Radford SE, Saibil HR. (2009) Globular tetramers of beta(2)-microglobulin assemble into elaborate amyloid fibrils. J. Mol Biol. 389(1), 48-57.

14. Okorokov AL, Orlova EV. (2009) Structural biology of the p53 tumour suppressor. Curr Opin Struct Biol. 19(2), 97-202. Review.

15. Fronzes R, Schäfer E, Wang L, Saibil HR, Orlova EV, Waksman G. (2009) Structure of a type IV secretion system core complex. Science. 323(5911), 266-268.

16. Salih O, Remaut H, Waksman G, Orlova EV. (2008) Structural analysis of the Saf pilus by electron microscopy and image processing. J Mol Biol. 23, 174-187

17. Elad N, Clare DK, Saibil HR, Orlova EV. (2008) Detection and separation of heterogeneity in molecular complexes by statistical analysis of their two-dimensional projections. J Struct Biol. 162, 108-120

18. Okorokov AL, Waugh A, Hodgkinson J, Murthy A, Hong HK, Leo E, Sherman MB, Stoeber K, Orlova EV, Williams GH. (2007) Hexameric ring structure of human MCM10 DNA replication factor. EMBO Rep. 10, 925-930

19. Plisson C, White HE, Auzat I, Zafarani A, São-José C, Lhuillier S, Tavares P, Orlova EV. (2007) Structure of bacteriophage SPP1 tail reveals trigger for DNA ejection. EMBO J. 26, 3720-3728

20. Lebedev AA, Krause MH, Isidro AL, Vagin AA, Orlova EV, Turner J, Dodson EJ, Tavares P, Antson AA. (2007) Structural framework for DNA translocation via the viral portal protein. EMBO J. 26, 1984-1994.

21. Elad N, Farr GW, Clare DK, Orlova EV, Horwich AL, Saibil HR. (2007) Topologies of a substrate protein bound to the chaperonin GroEL. Mol Cell. 26, 415-426.

22. Okorokov AL, Sherman MB, Plisson C, Grinkevich V, Sigmundsson K, Selivanova G, Milner J, Orlova EV. (2006) The structure of p53 tumour suppressor protein reveals the basis for its functional plasticity. EMBO J. 25/21, 5191–5200

23. Sherman MB, Guenther RH, Tama F, Sit TL, Brooks CL, Mikhailov AM, Orlova EV, Baker TS, Lommel SA. (2006) Removal of divalent cations induces structural transitions in red clover necrotic mosaic virus revealing a potential mechanism for RNA release. J Virol. 80(21), 10395-10406 (Front cover)

24. White HE, Orlova EV, Chen S, Wang L, Ignatiou A, Gowen B, Stromer T, Franzmann TM, Haslbeck M, Buchner J, Saibil HR. (2006) Multiple distinct assemblies reveal conformational flexibility in the small heat shock protein hsp26. Structure. 14, 1197-1204.

25. Orlova, EV & Saibil, HR (2004) Structure determination of macromolecular assemblies by single-particle analysis of cryo-electron micrographs. Current Opin. Struct. Biol. 14, 584-590.

26. White, HE, Saibil, HR, Ignatiou, A & Orlova, EV (2004) Recognition and separation of single particles with size variation by statistical analysis of their images. J. Mol. Biol. 336, 453-460.

EM group web page Elena Orlova