Image processing and single particle analysis

Challenges at the frontiers of structural biology. Saibil, HR & Orlova, EV (2002) Nature Struct. Biol. 9, 414-415.

Recognition and separation of single particles with size variation by statistical analysis of their images. White, HE, Saibil, HR, Ignatiou, A & Orlova, EV (2004) J. Mol. Biol. 336, 453-460.

Structure determination of macromolecular assemblies by single particle analysis of cryo-electron micrographs. E.V. Orlova & H.R. Saibil (2004) Curr. Opinion Struct. Biol. 14, 584-590.

Elad N, Farr GW, Clare DK, Orlova EV, Horwich AL, Saibil HR. Topologies of a substrate protein bound to the chaperonin GroEL. (2007) Mol Cell. 26, 415-426.

Elad N, Clare DK, Saibil HR, Orlova EV.Detection and separation of heterogeneity in molecular complexes by statistical analysis of their two-dimensional projections. (2007) J Struct Biol. Nov 22; [Epub ahead of print]