Professor Gabriel Waksman
EMBO member 2007 | Fellow of the Academy of Medical Sciences 2008
Malet Street
London WC1E 7HX
Tel 0207 631 6833
Fax 0207 631 6803
Email: g.waksman@mail.cryst.bbk.ac.uk or g.waksman@ucl.ac.uk
Education | Professional experience | Publications
Bachelor of Science in Physical Chemistry, University of Paris.
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University College London (UK). Head of Department of Biological Sciences, Birkbeck College (UK).
University of London (UK).
Birkbeck College and University College. University of London (UK).
Washington University School of Medicine, Saint Louis (USA).
Washington University School of Medicine, Saint Louis (USA).
Washington University School of Medicine, Saint Louis (USA)
Washington University School of Medicine, Saint Louis (USA)
Washington University School of Medicine, Saint Louis (USA)
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2011| 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997
G. Phan, H. Remaut, T.Wang, W. Allen, K. Pirker, A. Lebedev, N. Henderson, S. Geibel, E. Volkan, J. Yan, M. Kunze, J. Pinkner, B. Ford, C. Kay, H. Li, S. Hultgren, D. Thanassi*, and G. Waksman* (2011). Crystal structure of the FimD usher bound to its cognate FimC:FimH substrate. Nature.Article.474:49-53
A.C. Leney, G. Phan, W. Allen, D. Verger, G. Waksman,
S.E. Radford, and A.E. Ashcroft* (2011). Second order rate constants
of donor-strand exchange reveal individual amino acid residues important
in determining the subunit specificity of pilus biogenesis. J. Am. Soc.
Mass Spectrometry.In Press.
C. Ryan, M. Smith, F. Schumacher, D. Grohmann, D. Papaioannou, G.
Waksman, F. Werner, J. Baker*, S. Caddick* (2011). Tunable Reagents
for Multi-functional Bioconjugation: Reversible or Permanent Chemical
Modification
of Proteins and Peptides by Control of Maleimide Hydrolysis. Chemical
Communications.47 (19):5452-4
L.M. Banta*, J.E. Kerr, E. Cascales, M.E. Giuliano, M.E. Bailey, C.
McKay,G. Waksman, P.J. Christie* (2011). An Agrobacterium VirB10 Mutation
Conferring a Type IV Secretion Gating Defect.J. Bacteriology. 193(10):2566-74
N. Van Gerven, G. Waksman, and H. Remaut* (2011). Pili and flagella:
Biology, structure and biotechnological applications. In: Molecular Assembly
in Natural and Engineered Systems. Ed: Stefan Howorka. Academic Press.In
Press.
E. Durand, G. Waksman*, and V. Receveur-Brechot* (2011).Structural
insights into the membrane-extracted dimeric form of the ATPase TraB
from the Escherichia coli pKM101 conjugation system.BMC Structural
Biology.
11:4. p10-13.
L. Terradot* and G. Waksman* (2011).Architecture of the Helicobacter
pylori Cag- Type IV secretion system.FEBS Journal.278(8):1213-22.
X. Cai, R. Wang, A. Filloux, G. Waksman, G. Meng* (2011). Structural
and functional characterization of Pseudomonas aeruginosa CupB chaperones.
PLoS One.6(1):e16583.
S. Geibel and G. Waksman* (2011).Crystallography and EM of chaperone/usher
pilus systems. In “Bacterial Adhesion: Biology, Chemistry,
and Physics”. Editors: D. Linke and A. Goldman. Springer.715:159-74
K. Wallden, A. Rivera-Calzeda, and G. Waksman* (2010). Type IV secretion systems: diversity and versatility in function. Cell Microbiol. 12:1203-1212
G. Waksman* and R. Fronzes* (2010). Molecular architecture of type 4 secretion systems. TIBS.35:691 - 698
E. Chorell, J. Pinkner, G. Phan, S. Edvinsson, F. Buelens, H. Remaut, G. Waksman, S. Hultgren* and F. Almqvist* (2010). Design and synthesis of C-2 substituted thiazolo and dihydrothiazolo ring-fused 2-pyridones generate pilicides with increased antivirulence activity. J. Med. Chem. 53:5690-5695
E. Durand, C. Oomen and G. Waksman* (2010). Biochemical dissection of the ATPase TraB, the VirB4 homologue of the E. coli pKM101 conjugation machinery. J. Bacteriology. 192:2315-2323.
S. Virdee, D. MacMillan, and G. Waksman* (2010). Semisynthetic Src SH2 Domains Demonstrate Altered Phosphopeptide Specificity Induced by Incorporation of Unnatural Lysine Derivatives. Chemistry and Biology. 17:274-284
M.Smith, F.Schumacher. C.Ryan. L.Tedaldi, D.Papaioannou, G.Waksman, S.Caddick and J.Baker. (2010). Protein modification, bioconjugation, and disulfide bridging using bromaleimides. JACS. 132:1960-1965.
B.Ford, A. Toste Rego, T. Ragan, J. Pinkner, K. Dodson, P. Driscoll*, S. Hultgren* and G. Waksman* (2010). Structural homology between the C-terminal domain of the PapC usher and its plug. Journal of Bacteriology.192:1824-1831
A. Toste Rego, R. Fronzes and G.Wakman* (2010) Baterial appendages II. Cell Snapshot. 140:294
A. Toste Rego, R. Fronzes, and G. Wakman*(2010). Bacterial appendages I. Cell 140:162
A.Toste Rego, V. Chandran and G.Waksman* (2010). Two-step and one-step secretion mechanisms in Gram-negative bacteria: contrasting the type IV secretion system and the chaperone-usher pathway of pilus biogenesis. Biochem J. 425:475 - 488.
W.Allen, G.Phan and G.Waksman* (2009). Structural biology of periplasmic chaperones. Advances in Protein Chemistry and Structural Biology. 78:51-98
V. Chandran, R. Fronzes, S. Duquerroy, N. Cronin, J. Navaza, and G. Waksman* (2009). Crystal structure of the outer membrane complex of a type IV secretion system. Nature. 462:1011-1015.
R. Kenjale, G. Meng, D. Fink, T. Juehne, T. Ohashi, H. Erickson, G. Waksman, and J. St Geme 3rd * (2009). Structural determinants of autoproteolysis of the Haemophilus influenzae Hap autotransporter. Infect Immun. 77:4704-4713
G. Waksman* and S.J. Hultgren* (2009). Structure and assembly mechanism of chaperone-usher pili. Nature Reviews Microbiology. 7:703-714.
R. Fronzes, P. Christie*, and G. Waksman* (2009). Structural insights into type IV secretion machineries. Nature Reviews Microbiology. 7:703-714.
E. Durand, D. Verger, A. Toste-Rego, V. Chandran, G. Meng, R. Fronzes, G. Waksman (2009). Structural biology of bacterial secretion sytems in Gram-negative pathogens – Potential for new drug targets. Infectious Disorders - drug targets. 9:518-547.
J. Radin, S. Grass, G. Meng, S. Cotter, G. Waksman, and J. St Geme 3rd* (2009). Structural basis for the differential binding affinities of the HsfBD1 and HsfBD2 domains in the Haemophilus influenzae Hsf adhesin. J. Bacteriology. 191:5068-5075
G. Waksman* (2009). Going round in circles: the structural biology of type III secretion systems. Nature Structural and Molecular Biology. 16: 459-460.
R. Fronzes, E. Schaefer, L. Wang, H. Saibil, E. Orlova and G. Waksman* (2009). Structure of type IV secretion core complex. Science. 323:266-268.
G. Meng, R. Fronzes, V. Chandran, H. Remaut, and G. Waksman* (2009). Protein oligomerization in the bacterial outer membrane. Molecular Membrane Biology. 26:136-145.
H. Remaut and G. Waksman* (2008). Structure, function and bigenesis of pili formed by the chaperone/usher pathway. In: 'Fimbriae and Flagella: Current Research and Future Trends'. Ed. Ken F. Jarrell. 4:59-73
S.J. Jakubowski, J. Kerr, I. Garza, V. Krishnamoorthy, R. Bayliss, G. Waksman, and P.J. Christie* (2008). Agrobacterium VirB10 domain requirements for type IV secretion and T pilus biogenesis. Mol. Micro. 71:779-794.
G. Meng, J. StGemes and G. Waksman* (2008). Repetitive architecture of the Haemophilus influenzae Hia trimeric autotransporter. Journal of Molecular Biology. 384:824-836.
R. Fronzes, H. Remaut, and G. Waksman* (2008). Architectures and biogenesis of non-flagellar protein appendages in Gram-negative bacteria. New EMBO member review. EMBO Journal. 27:2271-2280.
D. Verger, R. Rose, E. Paci, G. Costakes, T. Daviter, S. Hultgren, H. Remaut, A. Ashcroft, S. Radford*, and G. Waksman* (2008). Structural and functional insights into the adaptor subunit function of PapF in pilus biogenesis. Structure. 16:1724-1731.
R. Rose, D. Verger, T. Daviter, H. Remaut, G. Waksman*, A Ashcroft*, and S. Radford* (2008). Unravelling the molecular basis of subunit specificity in P pilus assembly by mass spectrometry. Proc. Natl. Acad. Sci. USA. 105:12873-12878.
R.J. Rose, T.S. Welsh, G. Waksman, A.E. Ashcroft, S.E. Radford, and Emanuele Paci* (2008). Donor-strand exchange in chaperone-assisted pilus assembly revealed in atomic detail by molecular dynamics. J. Mol. Biol. 375(4):908-19.
R.J. S. Backert*, R. Fronzes, and G. Waksman (2008). VirB2/VirB5 proteins: specialized adhesins in bacterial type-IV secretion systems? Trends in Microbiology. 16:409-413.
W.J. Allen, P.J. Rothwell, and G. Waksman* (2008). An intramolecular FRET system monitors fingers subdomain opening in Klentaq1. Protein Science. 17:401-408.
G. De Fabritiis*, S. Geroult, P.V. Coveney* and G. Waksman* (2008). Insights from the energetics of water binding at the domain-ligand interface of the Src SH2 domain. PROTEINS: Structure, Function, and Bioinformatics. In press.
C. Bagneris, A. Ageichik, N. Cronin, B. Wallace, M. Collins, C. Boshoff, G. Waksman*, T. Barrett* (2008). Crystal structure of a vFlip-IKKg complex: Insights into viral activation of the IKK signalosome. Molecular Cell. 30:620-631.
H. Remaut, C. Tang, N.S. Henderson, J.S. Pinkner, T. Wang, S.J. Hultgren*, D.G. Thanassi*, G. Waksman*, H. Li* (2008). Fiber Formation Across the Bacterial Outer Membrane by the Chaperone/Usher Pathway. Cell. 133:640-652.
O. Salih, H. Remaut, G. Waksman and E. Orlova*. Structural Analysis of the Saf Pilus by Electron Microscopy and Image Processing. Journal of Molecular Biology. 379:174-187.
R. Bayliss, R. Harris, L. Coutte, A. Monier, R. Fronzes, P.J. Christie, P. Driscoll, and G. Waksman* (2007). NMR Structure of the VirB9/VirB7 interaction domains of pKM101: insight into type IV secretion assembly at the outer-membrane. Proc. Natl. Acad. Sci. USA. 104(5):1673-1678.
D. Verger, E. Bullitt*, S. Hultgren* and G. Waksman* (2007). Crystal structure of the P pilus rod subunit. PLoS Pathogens. 3(5):e73;001-009.
P.W. Fowler, S. Geroult, S. Jha, G. Waksman, and PV. Coveney* (2007) Rapid, Accurate, and Precise Calculation of Relative Binding Affinities for the SH2 Domain Using a Computational Grid. J. Chem. Theory Comput. 3:1193-1202.
P. Rothwell and G. Waksman* (2007). A pre-equilibrium before nucleotide binding limits fingers subdomain closure by Klentaq1. J. Biol. Chem. 282:28884-92.
S. Geroult, M. Hooda, S. Virdee and G. Waksman* (2007). Prediction of solvation sites at the interface of Src SH2 domain complexes using molecular dynamics simulations. Chemical Biology and Drug Design. 70:87-99.
S.Hare, W.Fischer, R. Williams, L. Terradot, R. Bayliss, R. Haas, and G. Waksman* (2007). Identification, structure and mode of action of a new regulator of the Helicobacter pylori HP0525 ATPase. EMBO Journal. 26(23):4926-34.
S. Geroult, S. Virdee, and G. Waksman* (2006). The role of water in computational and experimental derivation of binding thermodynamics of SH2 domains. Chemical Biology & Drug Design. 67:38-45.
S. Hare, R. Bayliss, C. Baron, and G. Waksman* (2006). A large domain swap in the VirB11 ATPase of Brucella suis leaves the hexameric assembly intact. Journal of Molecular Biology. 360:56-66.
R. Harris, R. Bayliss, G. Waksman*, and P.C. Driscoll* (2006). Resonance assignments of the complex between TraN and the C-terminal domain of TraO from the conjugative plasmid pKM101. J. Biol. NMR. 36 Suppl 5:31.
G. Meng, N.K. Surana, J. StGemes, and G. Waksman* (2006). Structure of the outer membrane translocator domain of the Haemophilus influenzae Hia trimeric autotransporter. EMBO Journal. 25:2297-304.
Paschos, G. Patey, D. Sivanesan, C. Gao, R. Bayliss, G. Waksman, D. O'Callaghan, C. Baron* (2006). Dimerization and interactions of Brucella suis VirB8 with VirB4 and VirB10 are required for its biological activity. Proceedings of the National Academy of Sciences (USA). 103(19):7252-7.
JS. Pinkner, H. Remaut, F. Buelens, E. Miller, V. Akberg, N. Pemberton, M. Hedenstrom, A. Larsson, P. Seed, G. Waksman*, SJ. Hultgren* & F. Almqvist*. New Class of Rationally Designed Small Compounds Inhibit Pilus Biogenesis in Uropathogenic Bacteria. Proc. Natl. Acad. Sci. USA. 103(47):17897-902.
H. Remaut, R.J. Rose, T.J. Hannan, S.J. Hultgren, S.E. Radford, A.E. Ashcroft, and G. Waksman* (2006). Donor-strand exchange in chaperone-assisted pilus assembly proceeds through a concerted beta-strand displacement mechanism. Molecular Cell. 22: 831-842.
H. Remaut and G. Waksman* (2006). Protein-protein interaction through beta-strand addition. TIBS. 34:436-444.
D. Verger, E. Miller, H. Remaut, G. Waksman* and S. Hultgren* (2006). Molecular mechanism of P pilus termination in uropathogenic E. coli. EMBO reports. 7:1228-32.
M. Duckely, C. Oomen, F. Axthelm, P. Van Gelder, G. Waksman, and A. Engel* (2005). The VirE1VirE2 complex of Agrobacterium tumefaciens interacts with ssDNA and forms channels. Mol. Microbiol. 58:1130-1142.
O.Y. Lubman, R. Kopan, G. Waksman, and S. Korolev* (2005). The crystal structure of a partial mouse Notch-1 ankyrin domain: repeats 4 through 7 preserve an ankyrin fold. Protein Science. 14:1274-1281.
P.J. Rothwell, V. Mitaksov, and G. Waksman* (2005). Motions of the fingers subdomain of the Klentaq1 DNA polymerase I enzyme are fast and not rate-limiting: implications for the molecular basis of fidelity in DNA polymerases. Molecular Cell. 19:345-355.
P.J. Rothwell and G. Waksman* (2005). Structure and mechanism of DNA polymerases. Advances in Protein Chemistry. 71:401-440
F.G. Sauer, S.J. Hultgren, and G. Waksman* (2005). The chaperone-usher pathway of pilus fiber biogenesis. In: Structural Biology of Bacterial Pathogenesis. ASM Press, G.Waksman, M. Caparon and S. Hultgren (Eds). pp 69-80.
G. Schroder, S.N. Savvides, G. Waksman, and E. Lanka* (2005). The type IV secretion machinery. In: Structural Biology of Bacterial Pathogenesis. ASM Press, G.Waksman, M. Caparon and S. Hultgren (Eds). pp179-222.
C.L. Smith, K. Dodson, G. Waksman, and S.J. Hultgren* (2005). Sugar recognition and bacterial attachment. In: Structural Biology of Bacterial Pathogenesis. ASM Press, G.Waksman, M. Caparon and S. Hultgren (Eds). pp37-48.
N.K. Surana, S.E. Cotter, H-J. Yeo, G. Waksman, J. StGemes* (2005). Structural determinants of Haemophilus influenzae adherence to host epithelium: Variations on type V secretion. In: Structural Biology of Bacterial Pathogenesis. ASM Press, G.Waksman, M. Caparon and S. Hultgren (Eds). pp129-148.
L. Terradot, R. Bayliss, C. Oomen, G. Leonard, and G. Waksman* (2005). Structures of two core subunits of the type IV secretion system, VirB8 from Brucella suis and ComB10 from Helicobacter pylori. Proceedings of the National Academy of Sciences (USA). 102:4596-4601.
G. Waksman* and C. Sansom (2005). Proteomics and Protein-Protein Interactions: Biology, Chemistry, Bioinformatics, And Drug Design. In: Proteomics and Protein-Protein Interactions: Biology, Chemistry, Bioinformatics, And Drug Design. Kluwer Press. G. Waksman (Ed).
G, Waksman* (2005). Structural biology of protein complexes. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. Wiley Ed.
T.M. Lohman*, J. Hsieh, N.K. Maluf, W. Cheng, A.L. Lucius, C.J. Fisher, K.M. Brendza, S. Korolev, and G.Waksman (2004). DNA helicases, motors that move along nucleic acids: lessons from the SF1 helicase superfamily. The Enzymes Vol 23. 304-371.
L. Terradot, Nathan Durnell, Ming Li, Daming Li, Jeremiah Ory, Agnes Labigne, Pierre Legrain, Frederic Colland, G. Waksman* (2004). Biochemical characterization of protein complexes from the Helicobacter pylori protein interaction map: strategies for complex formation and evidence for novel interactions within type IV secretion systems. Molec Cell Proteomics. 3:809-819.
A.O. Pineda, Zhi-Wei Chen, Sonia Caccia, Savvas N. Savvides, G. Waksman, F. Scott Mathews, and Enrico Di Cera* (2004). The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket. J. Biol. Chem. 279(38):39824-8.
H. Remaut and G. Waksman* (2004). Structural Biology of Bacterial pathogenesis. Current Opinion Structural Biology. 14:161-170.
F.G. Sauer, H. Remaut, S.J. Hultgren, and G. Waksman* (2004). Fiber assembly by the chaperone-usher pathway. Biochem. Biophys. Acta. 1694: 259-267.
S.N. Savvides, S. Raghunathan, K. Futterer, A.G. Kozlov, T.M. Lohman, and G. Waksman* (2004). The C-terminal domain of full length E. coli SSB is disordered even when bound to DNA. Protein Science. 13(7):1942-7.
G. Waksman*, S. Kumaran, and O. Lubman (2004). Thermodynamics of SH2 domain binding. In: Molecular Interpretation of Binding Thermodynamics. Editor: John Ladbury. John Wiley and Sons, Ltd. Chapter 8; 151-173.
G. Waksman*, S. Kumaran, and O. Lubman (2004). SH2 domains: Role, Structure, and Implications for Molecular Medicine. Exp. Rev. Mol. Med. 6:1-18.
G. Waksman and J. Kuriyan* (2004). Structure and specificity of the SH2 domain. Cell. 116:S45-48.
H-J Yeo, S.E. Cotter, S. Laarmann, T. Juehne, J.W. St. Geme, III*, and G. Waksman* (2004). Structural basis for host recognition by the Haemophilus influenzae Hia autotransporter. EMBO Journal. 23(6):1245-56.
H-J. Yeo, and G. Waksman* (2004). Unveiling molecular scaffolds of the type IV secretion system. Journal of Bacteriology. 186(7):1919-1926.
S. Kumaran, R.A. Grucza, and G. Waksman * (2003). The tandem SH2 domain of the Syk kinase: A Molecular Device that Adapts to Inter-phosphotyrosine Distances. Proceedings of the National Academy of Sciences (USA). 100:14828-14833.
O.Y. Lubman and G.Waksman * (2003). Structural and Thermodynamic Basis for the Interaction of the Src SH2 Domain with the Activated Form of the PDGF b -Receptor. Journal of Molecular Biology. 328:655-668.
S.N. Savvides, H-J. Yeo, M.R. Beck, F. Blaesing, R. Lurz, E. Lanka, R. Buhrdorf, W. Fischer, R. Haas and G. Waksman * (2003). VirB11 ATPases are dynamic hexameric assemblies: New insights into bacterial type IV secretion. EMBO Journal. 22:1969-1980.
H-J Yeo, Q. Yuan, M.R. Beck, C. Baron, and G. Waksman * (2003). Structural and functional characterization of the VirB5 protein from the type IV secretion system encoded by the conjugative plasmid pKM101. Proceedings of the National Academy of Sciences (USA). 100:15947-15952.
J.M. Brashaw and G. Waksman * (2002). Molecular recognition by SH2 domains. In: Advances in protein chemistry . Protein modules and protein-protein interactions. 61:161-210.
W. Cheng, K.M. Brendza, G.H. Gauss, S. Korolev, G. Waksman , and T.M. Lohman* (2002). The 2B domain of E. coli Rep helicase is not required for duplex DNA unwinding activity. Proceedings of the National Academy of Sciences (USA). 99:16006-11.
P. Davidson, O.Y Lubman, T. Rose, G. Waksman* , and S.F. Martin * (2002). Calorimetric and Structural Studies of 1,2,3-Trisubstituted Cyclopropanes as Conformationally Constrained Peptide Inhibitors of Src SH2 Domain Binding. JACS. 124:205-215.
C-S Hung, J. Bouckaert, D. Hung, R. Strouse, J. Pinkner, Charlotte Widberg, Anthony DeFusco, C. Gale Auguste, Robert Strouse, S. Langermann, G. Waksman *, and S.J. Hultgren* (2002). Structural Basis of Tropism of Escherichia coli to the Bladder during Urinary Tract Infection. Molecular Microbiology. 44:903-915.
O.Y. Lubman and G. Waksman * (2002). Dissection of the Energetic Coupling across the Src SH2 Domain- Tyrosyl Phosphopeptide Interface. Journal of Molecular Biology. 316:291-304.
A.G. Pineda, S. Savvides, G. Waksman , and E. Di Cera* (2002). Crystal structure of the anticoagulant slow form of thrombin. Journal of Biological Chemistry. 277:40177-80.
F. G. Sauer, J. Pinkner, G. Waksman *, and S.J.Hultgren (2002). Chaperone Priming of Pilus Subunit Facilitates a Topological Transition that Drives Fiber Formation. Cell. 111:543-51.
G. Schroder, S. Krause, E.L. Zechner, B. Traxler, H.-J. Yeo, R. Lurz, G. Waksman , and E. Lanka* (2002). TraG-like proteins of DNA transfer systems and of the Helicobacter pylori type IV secretion system: inner membrane gate for exported substrates? J Bacteriol. 184(10):2767-79.
G. Waksman * (2002). Hijacking the host cell proteasome. Developmental Cell. 3: 763-764.
H.-J. Yeo, G. Ziegelin S. Korolev, R. Calendar, E. Lanka, and G. Waksman* (2002). Phage P4 Origin-Binding Domain Structure Reveals a Mechanism for Regulation of DNA-Binding Activity by Homo- and Hetero-dimerization of Winged Helix Proteins. Molecular Microbiology. 43:857-870.
J.M. Bradshaw and G. Waksman * (2001). SH2 domains. Encyclopedia of Molecular Medicine . T.E. Creighton (Ed). pp 2900-2903.
K.W. Dodson, J.S. Pinkner, T. Rose, G. Magnusson, S.J. Hultgren*, and G. Waksman * (2001). Structural Basis of Tropism of Pyelonephritic E. coli for the Human Kidney. Cell. 105:733-743.
T.A. Farazi, G. Waksman , J.I. Gordon* (2001). The biology and enzymology of protein N-myristoylation. Journal of Biological Chemistry. 276:39501-4.
T.A. Farazi, J.K. Manchester, G. Waksman , and J.I. Gordon* (2001). Pre-steady state kinetic studies of Saccharomyces cerevisiae myristoylCoA:protein N-myristoyltransferase mutants identify residues involved in catalysis. Biochemistry. 40:9177-9186.
T.A. Farazi, G. Waksman , and J.I. Gordon* (2001). The structures of S. cerevisiae myristoylCoA: protein N-myristoyltransferase with bound myristoylCoA and peptide substrates provide insights about substrate recognition and catalysis. Biochemistry. 40:6335-6343.
K. Futterer, C.L. Murray, R.S. Bhatnagar, G.W. Gokel, J.I. Gordon, and G. Waksman* (2001). Crystallographic Phasing of Myristoyl-CoA:Protein N-Myristoyltransferase Using an Iodinated Analog of MyristoylCoA. Acta Cryst. D. 57: 393-400.
Ho, S.R. Schwarze, S.J. Mermelstein, G. Waksman , and S.F. Dowdy * (2001). Synthetic Protein Transduction Domains: Enhanced Transduction Potential in Vitro and in Vivo. Cancer Res. 61: 474-477.
Y. Li and G. Waksman * (2001). Crystal Structures of a ddATP-, ddTTP-, ddCTP-, and ddGTP-Trapped Ternary Complex of Klentaq1: Insights into Nucleotide Incorporation and Selectivity. Protein Science. 6:1225-1233.
Y. Li and G. Waksman* (2001). Structural studies of the Klentaq1 DNA polymerase. Current Organic Chemistry. Review. 5:871-884.
C. S. Ricard, J. M. Jakubowski, J. W. Verbsky, M. A. Barbieri, W. M. Lewis, G. E. Fernandez, M. Vogel, C. Tsou, V. Prasad, P. D. Stahl, G. Waksman , and C. M. Cheney * (2001). Drosophila rab GDI mutants disrupt development but have normal rab membrane extraction. Genesis. 31:17-29.
M.M. Barnhart, J.S. Pinkner, G.E. Soto, F.R. Sauer, S. Langermann, G. Waksman , C. Frieden, and S.J. Hultgren * (2000). PapD-like chaperone provide missing information for folding of pilin proteins. Proceedings of National Academy of Sciences (USA). 97:7709-7714.
R.S. Bhatnagar, K. Ashrafi, K. Futterer, G. Waksman , and J.I. Gordon * (2000). The biology and enzymology of protein N-myristoylation. The Enzymes . Protein lipidation, 3rd edition, F. Tamanoi and D.S. Sigman, Eds, pp241-172.
J.M. Bradshaw, R.A. Grucza, and G. Waksman* (2001). Binding thermodynamics of protein modules involved in tyrosine kinase signaling pathways. In: The thermodynamics of the drug-receptor interaction. R.B. Raffa Ed. pp451-470.
J.M. Bradshaw, V. Mitaxov, and G. Waksman* (2000). Mutational investigation of the specificity determining region of the Src SH2 domain. Journal of Molecular Biology. 299:521-535.
R.A. Grucza, J.M. Bradshaw, V. Mitaxov, and G. Waksman* (2000). The role of electrostatic interactions in SH2 domain recognition: salt-dependence of tyrosyl-phosphorylated peptide binding to the tandem SH2 domain of the Syk kinase and the single SH2 domain of the Src kinase. Biochemistry. 39:10072-10081.
Y. Li, and G. Waksman* (2000). Bacterial DNA polymerase I. In: Encyclopedia of Life Sciences.
S. Raghunathan, A.G. Kozlov, T.M. Lohman, and G. Waksman* (2000). Crystal structure of the homo-tetrameric DNA binding domain of E.coli SSB protein bound to single stranded DNA. Nature Structural Biology. 7:648-652.
F.G. Sauer, M. Barnhart, D. Choudhury, S.D. Knight, G. Waksman , S.J. Hultgren * (2000). Chaperone-assisted pilus assembly and bacterial attachment. Curr Opin Struct Biol. 10:548-56.
F.G. Sauer, S.D. Knight, G. Waksman , and S.J. Hultgren * (2000). PapD-like chaperones and pilus biogenesis. Seminars in Cell and Developmental Biology. 11:27-34.
G. Waksman* , E. Lanka, and G-M. Carazo (2000). Helicases, enzymatic motors in nucleic acid unwinding. Nature Structural Biology. 7:20-22.
H.-J. Yeo, S.N. Savvides, A.B. Herr, E. Lanka, and G. Waksman* (2000).Crystal structure of the hexameric traffic ATPase of the Helicobacter pylori Type IV secretion system. Molecular Cell. 6:1461-1472.
K. Yu, A.B. Herr, G. Waksman , and D.M. Ornitz * (2000). Loss of fibroblast growth factor receptor 2 ligand-binding specificity in Apert syndrome. Proceedings of National Academy of Sciences (USA). 97:14536-14541.
1999
R.S.Bhatnagar, K. Futterer, G. Waksman , and J.I. Gordon * (1999). Structure of MyristoylCoA: Protein N-myristoyltransferase. Biophysica and Biochemica Acta. 23;1441(2-3):162-172.
J.M. Bradshaw, V. Mitaxov, and G. Waksman* (1999). Investigation of phosphotyrosine recognition by the SH2 domain of the Src kinase. Journal of Molecular Biology. 293:971-985.
J.M. Bradshaw and G. Waksman* (1999). Calorimetric examination of high affinity Src SH2 domain-tyrosyl phosphopeptide binding: dissection of the phosphopeptide sequence specificity and coupling energetics. Biochemistry. 38:5147-5154.
J. Bubeck Wardenburg, J. Wong, K. Futterer, R. Pappu, C. Fu, G. Waksman , and A.C. Chan * (1999). Regulation of antigen receptor function by protein tyrosine kinases. Progress in Biophysical and Molecular Biology. 71:373-392.
R.A. Grucza, J.M. Bradshaw, K. Futterer, and G. Waksman* (1999). SH2 domains: from structure to energetics, a dual approach to the study of structure-function relationship. Medicinal Research Reviews. 19:273-293.
R.A. Grucza, K. Futterer, A.C. Chan, and G. Waksman* (1999). Thermodynamic study of the binding of the tandem-SH2 domain of the Syk kinase to a dually phosphorylated ITAM peptide: evidence for two conformers. Biochemistry. 38:5024-5033.
E.R. Guinto, S. Caccia, T. Rose, K. Futterer, G. Waksman , and E. Di Cera * (1999). Unexpected crucial role of residue 225 in serine proteases. Proceedings of the National Academy of Sciences (USA). 96:1852-1857.
Y. Li, V. Mitaxov, and G. Waksman* (1999). Structure-based design of novel Taq DNA polymerases with improved properties of dideoxynucleotide incorporation. Proceedings of the National Academy of Sciences (USA). 96:9491-9496.
D. Lu, K. Futterer, S. Korolev, X. Zheng, K. Tan, and G. Waksman , and J.E. Sadler * (1999). Crystal structure of enteropeptidase light chain complexed with an analog of the trypsinogen activation peptide. Journal of Molecular Biology. 292:361-373.
F.G. Sauer, K. Futterer, J.S. Pinkner, K.W. Dodson, S.J. Hultgren *, and G. Waksman* (1999). Structural basis of chaperone function and pilus biogenesis. Science. 285:1058-1061.
R.S. Bhatnagar, K. Futterer, T.A. Farazi, S. Korolev, C.L. Murray, E. Jackson-Machelski, G.W. Gokel, J.I. Gordon, and G. Waksman* (1998). Structure of N-myristoyltransferase with bound myristoylCoA and peptide substrate analogs. Nature Structural Biology. 5:1091-1097.
J.M. Bradshaw, R.A. Grucza, J.E. Ladbury, and G. Waksman* (1998). Probing the "two-pronged-plug two holed-socket model for the mechanism of binding of the Src SH2 domain to phosphotyrosyl peptides: a thermodynamic study. Biochemistry . 37:9083-9090.
J.M. Bradshaw and G. Waksman* (1998). A calorimetric investigation of proton linkage by monitoring both the enthalpy and association constant of binding: application to the interaction of the Src SH2 domain with a high affinity tyrosyl phosphopeptide. Biochemistry . 37:15400-15407.
E. Chung, D. Henriques, D. Renzoni, M. Zvelebil, J.M. Bradshaw, G. Waksman , C.V. Robinson, and J.E. Ladbury * (1998). Mass spectrometric and thermodynamic studies reveal the role of water molecules in complexes formed between SH2 domains and tyrosyl phosphopeptides. Structure. 6:1141-1151.
S. Korolev, N. Yao, T.M. Lohman, P. Weber, and G. Waksman* (1998). Comparisons between the structures of HCV and Rep helicases reveal structural similarities between SF1 and SF2 superfamilies of helicases. Protein Science. 7:605-610.
K. Futterer, J. Wong, R.A. Grucza, A.C. Chan, and G. Waksman* (1998). Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide. Journal of Molecular Biology. 281:523-537.
Y. Li, Y. Kong, S. Korolev, and G. Waksman* (1998). Crystal structures of the Klenow fragment of Thermus aquaticus DNA polymerase complexed with deoxyribonucleoside triphosphates. Protein Science. 7:1116-1123.
Y. Li, S. Korolev, and G. Waksman* (1998). Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation. EMBO Journal. 17:7514-7525.
J.P.P. Meijerink, A.J.B.M. Mensink, K. Wang, T.W. Sedlack, A.W. Sloetjes, T. de Witte, G. Waksman , and S. J. Korsmeyer * (1998). Hematopoietic malignancies demonstrate loss-of-function mutations of BAX. Blood. 91:2991-2997.
G. Waksman* and A.B. Herr (1998). New insights into heparin-induced FGF oligomerization. News and Views article. Nature Structural Biology. 5:527-530.
K. Wang, A. Gross, G. Waksman , and S.J. Korsmeyer * (1998). Mutagenesis of the BH3 domain of Bax idenfies critical residues for dimerization and killing. Molecular Cellular Biology. 18:6083-6089.
A.B. Herr, D.M. Ornitz, R. Sasisekharan, G. Venkataraman, and G. Waksman* (1997). Heparin-induced self-association of fibroblast growth factor-2. Evidence for two oligomerization processes. Journal of Biological Chemistry. 272:16382-16389.
S. Korolev, J. Hsieh, G. Gauss, T.M. Lohman, and G. Waksman* (1997). Major domain swivelling revealed by the crystal structure of binary and ternary complexes of E.coli Rep helicase bound to single-stranded DNA and ADP. Cell. 90:635-647.
D. Ornitz and G. Waksman* (1997). Fibroblast growth factor receptors. In: Growth factors and wound healing: basic science and potential clinical applications. T.R. Ziegler, G.F. Pierce, and D.N. Herndon Eds. Springer-Verlag New York. 151-174.
S. Raghunathan, C.S. Ricard, T.M. Lohman, and G. Waksman* (1997). Crystal structure of the homo-tetrameric DNA binding domain of Escherichia coli single-stranded DNA binding protein determined by multiwavelength x-ray diffraction on the selenomethionyl protein at 2.9 A resolution. Proceedings of the National Academy of Science (USA). 94:6652-6657.
P.H. Schlessinger, A. Gross, X-M Yin, K. Yamamoto, M. Saito, G. Waksman , and S.J. Korsmeyer * (1997). Comparison ofthe ion channel characteristics of pro-apoptotic Bax and anti-apoptotic Bcl-2. Proceedings of the National Academy of Science (USA). 94:11357-11362.
J. Zha, H. Harada, K. Osipov, J. Jockel, G. Waksman , and S.J. Korsmeyer * (1997). BH3 domain of BAD is required for heterodimerization with BCL-X L and pro-apoptotic activity. Journal of Biological Chemistry. 272:24101-24104.