Ajit Basak Homepage

Ajit Basak

Department of Crystallography
Birkbeck College
Malet Street
London WC1E 7HX
+44-171-631-6803 (FAX)
a.basak@mail.cryst.bbk.ac.uk (office)
A picture of me


Molecular Biology

1) Structure and function of bacterial toxins supported by a BBSRC Project Grant . We have now solved three crystal structures of the alpha-toxin from Clostridium perfringens . This protein is the key virulence determinant in gas-gangrene. One crystal structure (containing cadmium ions) shows the molecule in an active conformation. Another structure (cadmium free) shows a catalytically inactive form of the enzyme where entry to the active site is blocked. We have also proposed a model for its interaction with the cell membrane. Details will appear on the Web as soon as our paper is accepted.
2) Supramolecular organisation of the eye lens (MRC Programme Grant)
3) Molecular structure of eukaryotic release factors and their function in protein synthesis


1) Measurement and interpretation of X-ray diffuse scattering
2) Estimation of errors in macromolecular structure determination

Software Engineering

1) Development of a class library for bioinformatics (BBSRC Project Grant)
2) Development of software for visualising domain motions in protein crystals


1) MSc (Computer Modelling and Bioinformatics)
2) Organiser of the award winning Principles of Protein Structure on the Internet


Co-ordinator of teaching programmes

Any questions and bug reports to Ajit K Basak

Last updated 13 December 1997