Professor Neil Q. McDonald
Current Research
Selected Publications
Recognition of an intra-chain tandem 14-3-3 binding site within PKCepsilon.
Kostelecky B, Saurin AT, Purkiss A, Parker PJ, McDonald NQ.
EMBO Reports (2009) 10(9), 983-989.
Protein kinase C intervention: the state of play.
Roffey J, Rosse C, Linch M, Hibbert A, McDonald NQ, Parker PJ.
Curr Opin Cell Biol. (2009) Apr;21(2):268-79.
Molecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MAL.
Mouilleron S, Guettler S, Langer CA, Treisman R & McDonald NQ. EMBO J. (2008) 27 (23): 1-11
Structural and functional relationships of the XPF/Mus81 family of proteins.
Ciccia A, McDonald N & West SC. Annu Rev Biochem. (2008) 77: 259-287
Structure of a conserved dimerisation domain within the F-box protein Fbxo7 and the PI31
proteasome inhibitor.
Kirk R, Laman H, Knowles PP, Murray-Rust J, Lomonosov M, Meziane EK, McDonald NQ.
J. Biol. Chem. (2008) 8; 823(32) 22325-35.
Tes, a Specific Mena Interacting Partner, Breaks the Rules for EVH1 Binding.
Boeda B, Briggs DC, Higgins T, Garvalov BK, Fadden AJ, McDonald NQ & Way M.
Molecular Cell (2007) 28(6) :1071-1082
Redox-mediated substrate recognition by Sdp1 defines a new group of tyrosine phosphatases.
Fox GC, Shafiq M, Briggs DC, Knowles PP, Collister M, Didmon MJ, Makrantoni V, Dickinson RJ, Hanrahan S,
Totty N, Stark MJR, Keyse SM, & McDonald NQ. Nature (2007) 447:487-492.
Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM.
Ciccia A, Ling C, Coulthard R, Yan Z, Xue Y, Meetei AR, Laghmani el H,
Joenje H, McDonald N, de Winter JP, Wang W, West SC. Molecular Cell (2007) Feb 9;25(3):331-43.
Disruption of methylarginine metabolism impairs vascular homeostasis.
Leiper J, Nandi M, Torendel, B, Murray-Rust J, et al. & McDonald, NQ, Vallance, P.
Nature Medicine (2007) 13, 198-203
Structure and chemical inhibition of the RET tyrosine kinase domain.
Knowles PP, Murray-Rust J, Kjaer S, Scott RP, Hanrahan S, Santoro M, Ibanez CF, McDonald NQ.
Journal of Biological Chemistry (2006) 281, 33577-33587
Structure of an XPF endonuclease with and without DNA suggests a model for substrate recognition.
Newman M, Murray-Rust J, Lally J, Rudolf J, Fadden A, Knowles PP, White MF, McDonald NQ.
EMBO Journal (2005) 24: 895-905
Contact Information
School of Crystallography
Birkbeck College
Phone: +44-207-631-6824
E-mail:
n.mcdonald@mail.cryst.bbk.ac.uk
London Research Institute
Cancer Research U.K.
Phone: +44-207-269-3259
E-mail:
neil.mcdonald@cancer.org.uk
Last update 19th June 2007
