Professor Neil Q. McDonald

Current Research

Selected Publications

Structures of the Phactr1 RPEL Domain and RPEL Motif Complexes with G-Actin Reveal the Molecular Basis for Actin Binding Cooperativity
Mouilleron S, Wiezlak M, O'Reilly N, Treisman R & McDonald NQ. Structure (2012) Oct 2. pii: S0969-2126(12)00335-8. doi: 10.1016/j.str.2012.08.031

Structure of a Pentavalent G-Actin•MRTF-A Complex Reveals How G-Actin Controls Nucleocytoplasmic Shuttling of a Transcriptional Coactivator
Mouilleron S, Langer CA, Guettler S, McDonald NQ & Treisman R. Science Signalling (2011) 4 (177): ra40. (Front cover)

Mammal-restricted elements predispose human RET to folding impairment by HSCR mutations
Kjær S, Hanrahan S, Totty N & McDonald NQ. Nature Structural and Molecular Biology (2010) 17: 726-731.

Protein kinase C intervention: the state of play.
Roffey J, Rosse C, Linch M, Hibbert A, McDonald NQ, Parker PJ. Curr Opin Cell Biol. (2009) Apr;21(2):268-79.

Recognition of an intra-chain tandem 14-3-3 binding site within PKC-epsilon
Kostelecky B, Saurin AT, Purkiss A, Parker PJ, McDonald NQ. EMBO Rep. 2009 Sep;10(9):983-9.

Molecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MAL.
Mouilleron S, Guettler S, Langer CA, Treisman R & McDonald NQ. EMBO J. (2008) 27 (23): 1-11

Structural and functional relationships of the XPF/Mus81 family of proteins.
Ciccia A, McDonald N & West SC. Annu Rev Biochem. (2008) 77: 259-287

Structure of a conserved dimerisation domain within the F-box protein Fbxo7 and the PI31 proteasome inhibitor.
Kirk R, Laman H, Knowles PP, Murray-Rust J, Lomonosov M, Meziane EK, McDonald NQ. J. Biol. Chem. (2008) 8; 823(32) 22325-35.

Tes, a Specific Mena Interacting Partner, Breaks the Rules for EVH1 Binding.
Boeda B, Briggs DC, Higgins T, Garvalov BK, Fadden AJ, McDonald NQ & Way M. Molecular Cell (2007) 28(6) :1071-1082

Redox-mediated substrate recognition by Sdp1 defines a new group of tyrosine phosphatases.
Fox GC, Shafiq M, Briggs DC, Knowles PP, Collister M, Didmon MJ, Makrantoni V, Dickinson RJ, Hanrahan S, Totty N, Stark MJR, Keyse SM, & McDonald NQ. Nature (2007) 447:487-492.

Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM.
Ciccia A, Ling C, Coulthard R, Yan Z, Xue Y, Meetei AR, Laghmani el H, Joenje H, McDonald N, de Winter JP, Wang W, West SC. Molecular Cell (2007) Feb 9;25(3):331-43.

Disruption of methylarginine metabolism impairs vascular homeostasis.
Leiper J, Nandi M, Torendel, B, Murray-Rust J, et al. & McDonald, NQ, Vallance, P. Nature Medicine (2007) 13, 198-203

Structure and chemical inhibition of the RET tyrosine kinase domain.
Knowles PP, Murray-Rust J, Kjaer S, Scott RP, Hanrahan S, Santoro M, Ibanez CF, McDonald NQ. Journal of Biological Chemistry (2006) 281, 33577-33587 (Front cover)

Structure of an XPF endonuclease with and without DNA suggests a model for substrate recognition.
Newman M, Murray-Rust J, Lally J, Rudolf J, Fadden A, Knowles PP, White MF, McDonald NQ. EMBO Journal (2005) 24: 895-905

Contact Information

School of Crystallography
Birkbeck College
Phone: +44-207-631-6824
London Research Institute
Cancer Research U.K.
Phone: +44-207-269-3259

Last update 1st November 2012