Image processing and single particle analysis

Conformational changes studied by cryo electron microscopy. Saibil, HR (2000) Nature Struct. Biol. 7, 711-714.

Macromolecular structure determination by cryo-electron microscopy. Saibil, HR (2000) Acta Cryst. D 56, 1215-1222.

Macromolecular Assemblages: Machines and networks. Saibil HR & Brunger AT, Eds. (2002) Curr Opin Struct Biol. 12.

Challenges at the frontiers of structural biology. Saibil, HR & Orlova, EV (2002) Nature Struct. Biol. 9, 414-415.

Recognition and separation of single particles with size variation by statistical analysis of their images. White, HE, Saibil, HR, Ignatiou, A & Orlova, EV (2004) J. Mol. Biol. 336, 453-460.

Structure determination of macromolecular assemblies by single particle analysis of cryo-electron micrographs. E.V. Orlova & H.R. Saibil (2004) Curr. Opinion Struct. Biol. 14, 584-590.

Elad N, Clare DK, Saibil HR, Orlova EV (2008) Detection and separation of heterogeneity in molecular complexes by statistical analysis of their two-dimensional projections. J Struct Biol.162, 108-120.

Saibil, HR (2007) How to read papers on three-dimensional structure determination by electron microscopy. in Evaluating techniques in biomedical research, Cell Press, on line.

Orlova, EV & Saibil, HR (2010) Methods for three-dimensional reconstruction of heterogeneous assemblies. Methods Enzymol. 482, 321-341.

Orlova, EV & Saibil, HR (2011) Structural analysis of macromolecular assemblies by electron microscopy. Chem. Rev. 111, 7710-7748.