|Antibody Name: ||
Sha, Y. and Xiang, J.
"A heavy-chain grafted antibody that recognizes the tumor-associated TAG72 antigen"
Canc. Biother. (1994) 9:341-349.
|Donor Antibody: ||
|Acceptor Antibody: ||
Human IgG1 | mouse k
Tumour Associated Glycoprotein (TAG72) (Epitope sialosyl-Tn)
University of Saskatchewan, Canada
Chose NEWM FR because it had successfully been used in B1.8.
human VH NEWM | VL k mouse
All 3 VH, Kabat Definition, except that residues 26-30:H were retained.
None, except those in residues 26-30:H.
Low compared with murine and chimaeric as measured by ELISA and Western
VkCk cell line derived from myeloma SP2/0Ag14
NEWM FRs had low homology, EU FRs would be better.
|Clinical Indication: ||
Colorectal, gastric and ovarian carcinomas.