|Antibody Name: ||
Eigenbrot, C., Gonzalez, T., Mayeda, J., Carter, P., Werther, W., Hotaling, T.,
Fox, J. and Kessler, J.
"X-ray structures of fragments from binding and nonbinding versions of a humanized anti-CD18 antibody: Structural indications of the Key role of VH residues 59-65"
Proteins (1994) 18:49-62.
|Donor Antibody: ||
|Acceptor Antibody: ||
Human IgG1 | k
B2-subunit (CD18) of integrins (LFA-1, Mac-1, P150,95)
Common FR derived from consensus sequences of the most common human isotypes (VHIII, VkI).
VH SGIII | VL kI consensus sequences.
All 6 VH and VL, Kabat Definition.
To be discussed in forthcoming publication by M. Zoller.
"Approaches" the affinity of the chimaeric mAb by competition binding. Best
Structures show the importance of the C-terminal region of CDR-H2 (residues
|Clinical Indication: ||
"Potential to ameliorate deleterious immunological and inflammatory processes".