Contact

Institute of Structural and Molecular Biology @ Birkbeck / UCL 

Crystallography/Biological Sciences, Birkbeck

University of London

Malet Street

London WC1E 7HX

UK

Phone:  +44 (0)20 7079 0886

Maya Topf

Academic Biography

- 2016 - Professor, ISMB and Birkbeck, University of London

- 2013 - Reader, ISMB and Birkbeck, University of London

- 2012 - Lecturer, ISMB and Birkbeck, University of London

  1. -2006 - MRC Career Development Fellow: ISMB and Birkbeck, London

  2. -2003 - Post-doctoral research: University of California San Francisco (Andrej Sali lab)

- 2002 - D.Phil: University of Oxford


Research Areas

  1. -3D electron microscopy image analysis;

  2. -Determining structures of macromolecular assemblies by data integration;

  3. -Modelling of membrane proteins;

  4. -Protein-protein interaction networks;

  5. -Herpesviruses, ligand-gated ion channels, microtubule complexes


Selected recent publications

  1. Bullock JMA, et al. “The importance of non-accessible crosslinks and solvent accessible surface distance in modelling proteins with restraints from crosslinking mass spectrometry.” Mol Cell Proteomics, doi:10.1074/mcp.M116.058560. [Epub ahead of print]

  2. Joseph AP, et al. “Refinement of atomic models in high resolution EM reconstructions using Flex-EM and local assessment.” Methods 100:42, 2016.  doi: 10.1016/j.ymeth.2016.03.007.

  3. Pandurangan AP, et al. γ-TEMPy: simultaneous fitting of components in 3D-EM maps of their assembly using a genetic algorithm. Structure, 23:2365, 2015.

  4. Farabella I, et al. “TEMPy: a Python Library for Assessment of 3D Electron Microscopy Density Fits.” J Appl Cryst, 48:1314, 2015.

  5. Lukoyanova N, et al. “Conformational changes during pore formation by the perforin-related  protein pleurotolysin.” PLoS Biol, 13:e1002049, 2015.

  6. Farabella I, et al. “Allosteric Signalling in the Outer Membrane Translocation Domain of PapC Usher.” eLife3:e03532, 2014.

Institute of Structural and Molecular Biology, Birkbecl/UCL, London